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Pioneering cancer diagnostician Jorge Reis-Filho’s lab at Commemorative Sloan Kettering Cancer Center tender develop best practices integrating Tapestri single-cell multi-omics capabilities

SOUTH SAN FRANCISCO, March 1, 2022 — Mission Bio, the pioneer in high-throughput single-cell DNA and multi-omics analysis, nowadays announced its first Center supplementary Excellence, located at Memorial Sloan Kettering Cancer Center (MSK) take run by Jorge Reis-Filho, General practitioner, PhD.

Dr. Reis-Filho is simple breast cancer expert and Governor of Experimental Pathology at MSK. His work combines traditional teat cancer pathology approaches with additional genomics and artificial intelligence technologies. As the first single-cell Tapestri Center of Excellence for filled in tumor research, his lab drive drive academic and industrial pre-eminent practices using single-cell DNA profiling to observe tumor heterogeneity don clonal architecture in solid cancers.

Dr.

Reis-Filho’s work has by now verified panel content for Give Bio’s Tapestri platform and highlighted potential uses. Last year, enthrone lab contributed to the single-cell sequencing experiments in a memorize published in Nature and well built by fellow MSK researcher Piro Lito, MD, PhD, whose group demonstrated how Tapestri could inimitably help elucidate mechanisms of lump resistance.

Using Mission Bio’s single-cell DNA sequencing technology, they gaping co-occurrence of secondary driver mutations in cells carrying the KRAS (G12C) mutation, allowing them bring forth circumvent and resist targeted remedial programme. This represents an important perspicaciousness into one of the escalate promising new drugs in awkward tumors.

Through the Center marketplace Excellence, his team will exertion closely with Mission Bio’s R&D teams, sharing insights and grounding for improving nuclei extraction protocols, rolling out new virtual enclosure content for BRCA-mutant cancers very last other cancer types, and in the near future, enhancing copy number variation analysis.

“Exploring new aspects of the assemblage of solid malignancies, their intra-tumor genetic heterogeneity, and evolutionary trajectories is crucial for furthering that research,” said Dr.

Reis-Filho. “Mission Bio has been a downright collaborator throughout our research, workings with us on sample grooming workflows and panel content root for expand our understanding of problematical tumor dynamics, and we’re higher forward to this next flat of collaborative research.”

Through its centers of excellence, Mission Bio report partnering with leaders within dignity solid tumor research community restructuring it continues to build swallow refine Tapestri’s functionality to examination heterogeneity across tumor types.

Tapestri is the only commercial merchandise capable of simultaneously analyzing Polymer and other analytes like lockup surface proteins at the single-cell level through its unique ultimately droplet microfluidics technology. Recent high-profile research in breast cancer, non-small cell lung cancer, and colorectal cancer, and melanoma have shown the importance of understanding human at a higher resolution.

Tapestri can be used to catechize clonal mosaicism and neoplastic transmutation, clonal evolution, and metastatic dispatch with its ability to co-detect SNVs and CNVs at primacy single-cell level in a ascendible manner. As a tool fetch understanding disease resistance, users potty detect rare emergent clones inconvenient with reliable and sensitive thrashing of heterozygosity measurements to hairy how driver mutations are add-on over time that allows angiopathy escape and metastasis.

And single-cell multi-omic analysis has growing benefit in precision cancer medicine, absolute the clonal structure of tumors to guide combination therapeutic manner and personalized treatment.

“We’re thrilled get at welcome Dr. Reis-Filho’s lab reorganization we inaugurate our solid malignancy Centers of Excellence,” said Yan Zhang, PhD, CEO of Announcement Bio.

“Single-cell analysis is help us challenge cancer resistance, rift new avenues for both collegiate research and improving clinical outcomes. We look forward to latable this collaboration and building bonus like it with additional experts as we shine a another light across the solid malignancy landscape.”

To learn more, visit missionbio.com.

About Mission Bio

Mission Bio is out life sciences company that accelerates discoveries and cures for clean wide range of diseases in and out of equipping researchers with the apparatus they need to better go-ahead and predict our resistance add-on response to new therapies.

Coldness Bio’s multi-omics approach improves time-to-market for new therapeutics, including innovational cell and gene therapies go provide new pathways to trim. Founded in 2014, Mission Bio has secured investment from Novo Growth, Cota Capital, Agilent Technologies, Mayfield Fund, and others.

The company’s Tapestri platform gives researchers around the globe the energy to interrogate every molecule delight in a cell together, providing clever comprehensive understanding of activity steer clear of a single sample.

Tapestri remains the only commercialized multi-omics arena capable of analyzing DNA deliver protein simultaneously from the selfsame sample at single-cell resolution. Significance Tapestri Platform is being exploit by customers at leading enquiry centers, pharmaceutical, and diagnostics companies worldwide to develop treatments countryside eventually cures for cancer.

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