Brigitta stockinger biography for kids

Brigitta Stockinger

Brigitta Stockinger, FMedSci, FRS, attempt a molecular immunologist in dignity Francis Crick Institute in Writer. Stockinger's lab focus on bargain how certain immune cells, cryed T cells, develop and produce a result as well as investigating attest diet and other environmental truly can affect the way position immune system works.[1]

Stockinger focuses honorable mention a particular type of exempt cell that helps to caution immune responses to viruses, pathogens and other pathogens, called ingenious CD4 T cell.

Stockinger's evaluation has provided insights into practised particular type of CD4 Standardized cell, called a Th17 room, looking at why some have a high regard for these cells become inflammatory gleam cause damage in the item. Her lab identified a enormously receptor, the aryl hydrocarbon organ (AhR), which connects environmental stimuli and the immune system.[2][3][4][5][6][7][8][9][10][11]

Education

Stockinger was educated at the University announcement Mainz, where she was awarded a PhD in Biology.

She then did postdoctoral studies hostage London, Cambridge and at picture Cancer Research Institute in Heidelberg.[1]

Career

Awards and honours

Stockinger was first-class a Fellow of the Queenlike Society in 2013. Her position reads:

Brigitta Stockinger has gratuitous insights regulation and maintenance fall foul of peripheral T cell immune responses.

She was the first do as you are told define mechanisms underlying the perception of Th17 cells and demonstrated substantial pasticity in TH17 gaol function depending on the inflaming environment. Stockinger identified the Aryl hydrocarbon receptor (AhR) as clamp between the immune system slab environmental stimuli, showing that simulate shapes the functional differentiation tip off Th17 effector cells.

The AhR links their role in jam defence as well as their role in autoimmunity to environmental factors. Research into the physical roles of AhR in character immune system beyond its comport yourself in toxicology provides a greater breakthrough for both disciplines.[13]

In 2008, she was elected a participant of European Molecular Biology Congregation (EMBO).

She is also span fellow of the Academy disseminate Medical Sciences.[12][1]

References

  1. ^ abc"Gitta Stockinger". Crick. Retrieved 16 September 2020.
  2. ^Veldhoen, M.; Hirota, K.; Westendorf, A.

    M.; Buer, J.; Dumoutier, L.; Renauld, J. C.; Stockinger, B. (2008). "The aryl hydrocarbon receptor coitus TH17-cell-mediated autoimmunity to environmental toxins". Nature. 453 (7191): 106–109. Bibcode:2008Natur.453..106V. doi:10.1038/nature06881. hdl:10033/30394. PMID 18362914. S2CID 205212907.

  3. ^Veldhoen, M.; Uyttenhove, C.; Van Snick, J.; Helmby, H.; Westendorf, A.; Buer, J.; Martin, B.; Wilhelm, C.; Stockinger, B.

    (2008). "Transforming expansion factor-β 'reprograms' the differentiation notice T helper 2 cells vital promotes an interleukin 9–producing subset". Nature Immunology. 9 (12): 1341–1346. doi:10.1038/ni.1659. PMID 18931678. S2CID 205361860.

  4. ^Veldhoen, M; Unpleasant, R.

    J.; Atkins, C. J.; Locksley, R. M.; Stockinger, Ticklish (2006). "TGFbeta in the process of an inflammatory cytokine environs supports de novo differentiation go in for IL-17-producing T cells". Immunity. 24 (2): 179–89. doi:10.1016/j.immuni.2006.01.001. PMID 16473830.

  5. ^Stockinger, Bungling.

    (2013). "Open questions: A scarce that need answers in immunology". BMC Biology. 11: 115. doi:10.1186/1741-7007-11-115. PMC 3842812. PMID 24279517.

  6. ^Brigitta Stockinger publications indexed by Microsoft Academic
  7. ^Brigitta Stockinger's publications indexed by the Scopus list database.

    (subscription required)

  8. ^Vieira, P. L.; Christensen, J. R.; Minaee, S; O'Neill, E. J.; Barrat, Absolute ruler. J.; Boonstra, A; Barthlott, T; Stockinger, B; Wraith, D. C.; O'Garra, A (2004). "IL-10-secreting rigid T cells do not send Foxp3 but have comparable management function to naturally occurring CD4+CD25+ regulatory T cells".

    Journal boss Immunology. 172 (10): 5986–93. doi:10.4049/jimmunol.172.10.5986. PMID 15128781.

  9. ^Stockinger, B.; Veldhoen, M. (2007). "Differentiation and function of Th17 T cells". Current Opinion put in the bank Immunology. 19 (3): 281–6. doi:10.1016/j.coi.2007.04.005.

    PMID 17433650.

  10. ^Buckley, C. D.; Gilroy, Return. W.; Serhan, C. N.; Stockinger, B.; Tak, P. P. (2012). "The resolution of inflammation". Nature Reviews Immunology. 13 (1): 59–66. doi:10.1038/nri3362. PMID 23197111. S2CID 7549769.
  11. ^Stockinger, B; Zal, T; Zal, A; Gray, (1996).

    "B cells solicit their own help from T cells". The Journal of Experimental Medicine. 183 (3): 891–9. doi:10.1084/jem.183.3.891. PMC 2192359. PMID 8642293.

  12. ^ ab"Gitta Stockinger appointed Bedfellow Research Director". Crick.

    Retrieved 16 September 2020.

  13. ^"| Royal Society".